Lipid Profiling And The Effect Of SRGAP2 (Rs2580520) Polymorphism on The Serum Lipid Levels In Multiple Psychiatric Disorders In The Pakistani Population

Introduction: The link between lipid profiles and various neuropsychiatric conditions has been studied; however, few studies have systematically pooled data to examine comparative associations between lipid components and multiple psychiatric conditions. Therefore, the current study aimed to conduct a comparative analysis of lipid components, their relationship with suicidality, and the effect of the SRGAP2 (rs2580520) polymorphism on serum lipid levels in major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SHZ) in the Pakistani population. Methods: The rs2580520 was genotyped using the tetra-amplification refractory mutation system-PCR (TETRA-ARMS-PCR), and the CHOD/POD (Cholesterol oxidase/Peroxidase) method was used for serum lipid profiling. Results: A significant association of the rs2580520 risk allele (C) with suicidality in MDD (p<0.01) was found. Significantly lower levels of total cholesterol (TCH), highdensity lipids (HDL), and low-density lipids (LDL) were observed in MDD, BD, and SHZ (p<0.05). However, significantly elevated total lipid (TL) levels were observed in MDD (p<0.05) and lower TL levels in BD (p<0.05) compared to controls. This study also observed significantly lower serum TCH, LDL, HDL, and TL levels in the suicidal BD group (p<0.05). Discussion: The findings of this study support the hypothesis that the variation in lipid levels is associated with MDD, BD, and SHZ. The lower lipid component levels may serve as a potential biomarker of suicidality in BD, while the elevated serum TL levels may be linked to MDD. Conclusion: The study findings highlight the potential role of lipid component levels as biomarkers in psychiatric conditions, although further longitudinal studies are required to clarify causal relationships.