PIII-Chelation-Enabled Ni(0)-Catalyzed Alkenylation of Nonacidic C–H in Biarylphosphines with Alkynes
Abstract A P(III)-chelation-assisted Ni(0)-catalyzed C–H alkenylation of biarylphosphines with alkynes is reported, enabling the functionalization of nonacidic arene C–H bonds without a stoichiometric base. The protocol accommodates a broad range of biarylphosphines and alkynes, affording diversely alkenylated biaryl monophosphines in up to 94% yield. Mechanistic studies confirm irreversible C–H cleavage as the rate-determining step. This work provides a sustainable and cost-effective alternative to precious-metal-based methods for the late-stage diversification of biaryl phosphine ligands.
Authors
- Xiangkai Kong (ORCID: https://orcid.org/0000-0002-0552-5557)
- Jianta Wang (ORCID: https://orcid.org/0000-0002-2007-0925)
- Bo Li (ORCID: https://orcid.org/0000-0002-4279-4596)
- Rong-Hua Wang (ORCID: https://orcid.org/0000-0002-3862-9686)
- Ming-Bai Gou
- Chun-Min Yang
- Jiayu Huang
- Hong-Ji Zhao
- Lei Tang
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-09-11
- DOI
- https://doi.org/10.1021/acs.orglett.6c03293
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guizhou Science and Technology Department
- Natural Science Foundation of Guizhou Province
- Guizhou Medical University