VISTA: a classifier for metagenomic subspecies and community state typing of the vaginal microbiome

ABSTRACT Metagenomic community state types (mgCSTs) capture within-species genetic and functional diversity and community structure of the vaginal microbiome, enabling precise links between microbiome composition, function, and health-related risk. VISTA, the V aginal I nference of S ubspecies and T yping A lgorithm, is a two-step classifier that assigns mgCSTs to vaginal metagenomes, providing standardized, scalable classifications.