Heterologous adenovirus A2/Leish-Tec® vaccination strategy in a murine model of visceral leishmaniasis: Potential canine vaccine with enhanced protection and potent T-cell immunity

T lymphocytes after antigen stimulation. Overall, the AdA2+LT heterologous strategy outperformed the other regimens and represents a promising vaccination approach against visceral leishmaniasis.

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Publication Details

Journal
Vaccine
Published
2026-09-11
DOI
https://doi.org/10.1016/j.vaccine.2026.129105
Primary Topic
Virus-based gene therapy research
Type
article
Field-Weighted Citation Impact
0.00

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article

Heterologous adenovirus A2/Leish-Tec® vaccination strategy in a murine model of visceral leishmaniasis: Potential canine vaccine with enhanced protection and potent T-cell immunity

Ricardo Toshio Fujiwara, Ana Laura Grossi de Oliveira, Tatyane Martins Cirilo, Rodrigo Santos Da Silva et al.
Vaccine
Virus-based gene therapy research
article

Heterologous adenovirus A2/Leish-Tec® vaccination strategy in a murine model of visceral leishmaniasis: Potential canine vaccine with enhanced protection and potent T-cell immunity

Ricardo Toshio Fujiwara, Ana Laura Grossi de Oliveira, Tatyane Martins Cirilo, Rodrigo Santos Da Silva, Oscar Bruña–Romero, Isabela de Brito Duval, Fabíola de Oliveira Paes Leme, Luísa Mourão Dias Magalhães, Marianna de Carvalho Clímaco, Eduardo Antônio Ferraz Coelho, Jorge Lucas Nascimento Souza, Marcelo Eduardo Cardozo, Lilian Lacerda Bueno, Flaviane Vieira Santos, Ana Carolina Amado-Gomes, Ramayanna Morais de Medeiros Brito
article en

Abstract

T lymphocytes after antigen stimulation. Overall, the AdA2+LT heterologous strategy outperformed the other regimens and represents a promising vaccination approach against visceral leishmaniasis.

VaccineVol. 92
Universidade Federal de Minas Gerais (BR), Universidade Federal de Sergipe (BR), Universidade Federal de Santa Catarina (BR)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de Minas Gerais
Zero hunger
Openalex Percentile: Top 11%
Virus-based gene therapy research
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