The Hcp2b protein of APEC induces defective autophagy in HD11 cells by causing lysosomal dysfunction
RESEARCH HIGHLIGHTS: APEC Hcp2b protein translocates into HD11 cells and induces significant cytotoxicity.Hcp2b elicits incomplete autophagy, characterized by blocked autophagic flux.Proteomic analysis demonstrated Hcp2b impairs lysosomes, blocking autophagy.
Authors
- Jiumeng Sun (ORCID: https://orcid.org/0000-0003-2549-4812)
- Ying Shao (ORCID: https://orcid.org/0000-0002-0390-3315)
- Yaqin Tian
- Xiangjun Song (ORCID: https://orcid.org/0000-0002-8044-9961)
- Mengling Peng
- Jingwen Zhang (ORCID: https://orcid.org/0000-0003-4071-4449)
- Mei Xue (ORCID: https://orcid.org/0000-0002-2901-2801)
- Liting Lu (ORCID: https://orcid.org/0000-0002-8277-5576)
- Jian Tu
- Zhengyu Wang
- Shuhui Wang
Institutions
- Anhui Agricultural University (CN)
- Jinling Institute of Technology (CN)
Publication Details
- Journal
- Avian Pathology
- Published
- 2026-09-11
- DOI
- https://doi.org/10.1080/03079457.2026.2717141
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Anhui Province
- Excellent Young Talents Fund Program of Higher Education Institutions of Anhui Province
- Food Science and Nutrition Research Center
- Joint Fund for Aerospace Advanced Manufacturing Technology Research