Polysubstituted Fluoroalkylalkene Formation through Photoredox/Copper Dual Catalysis
Abstract Herein, we have developed photoredox/copper dual catalysis for the synthesis of structurally useful polysubstituted fluoroalkylalkenes. The cascade reaction involves defluoronative difluoroalkyl radical formation, radical addition to vinylene carbonate, radical-metal binding, β-elimination, and decarboxylation. This approach efficiently affords stereoregular tri- and tetrasubstituted fluoroalkyl alkenes with broad functional group tolerance.
Authors
- Xiaochen Ji (ORCID: https://orcid.org/0000-0001-9533-0376)
- Huawen Huang (ORCID: https://orcid.org/0000-0001-7079-1299)
- Mengqi Zhu (ORCID: https://orcid.org/0000-0002-1404-0818)
- Guo‐Jun Deng (ORCID: https://orcid.org/0000-0003-2759-0314)
- Dongfang Jiang (ORCID: https://orcid.org/0009-0006-3644-7519)
Institutions
- Hunan Institute of Science and Technology (CN)
- Changsha Medical University (CN)
- Xiangtan University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-09-11
- DOI
- https://doi.org/10.1021/acs.orglett.6c03567
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Hunan Provincial Innovation Foundation for Postgraduate