Evaluation of reflexive, hearing-targeted congenital cytomegalovirus screening at a high-volume center

Abstract Objective Examine congenital cytomegalovirus (cCMV) testing practices before and after implementation of a hospital-wide, reflexive, hearing-targeted screening policy. Study design 91079 infants from 2016 to 2023 were included retrospectively from our center. cCMV testing and diagnosis rates were compared before and after implementation of a provider cCMV education program and policy automating a nursing order for cCMV test prior to discharge after referred NBHS. Result The proportion of infants with referred NBHS who underwent cCMV screening increased after implementation compared to prior (7.7% versus 95.2%, p < 0.0001). cCMV screening for non-hearing-related cCMV indicators also increased (0.9% versus 3.3%, p < 0.0001). cCMV positivity rates prior to and after implementation were 0.015% and 0.036%, respectively ( p = 0.053). Conclusion This hospital-wide, reflexive, hearing-targeted screening policy was associated with significantly improved cCMV screening rates and may enhance early cCMV detection, supporting standardized hospital-specific protocols and education to implement state mandates.