PARENTERAL CONTROLLED DRUG DELIVERY SYSTEM A MODERN FORMULATION APPROACH

The Parenteral administration route is the most common and efficient for delivery of active drug substances with poor bioavailability and the drugs with a narrow therapeutic index. But parenteral route offers rapid onset of action with rapid declines of systemic drug level. For the sake of effective treatment, it is often desirable to maintain systemic drug levels within the therapeutic effective concentration range for as long as treatment calls for. It requires frequent injections, which ultimately leads to patient discomfort. For this reason, the drug delivery system can reduce the total number of injections throughout the effective treatment, improve patient compliance, as well as pharmacoeconomic. These biodegradable injectable drug delivery systems offer attractive opportunities for protein delivery and could possibly extend patent life of protein drugs. This article explores various prolonged release of parenteral drug delivery systems and their strategies of preparation, their potential benefits/drawbacks, and in-vitro testing methods.