Nanostructured Electrochemical Biosensor for Highly Sensitive Copeptin Detection as a Cardiac Biomarker
Abstract Copeptin is an important biomarker for the diagnosis of acute myocardial infarction in the troponin-blind period. In this study, a peptide-based nanostructured electrochemical biosensor was developed on a screen-printed electrode platform, enabling a disposable sensing strategy suitable for on-site applications. A copeptin-specific peptide, synthesized for this study, was employed as the biorecognition element to provide binding sites for the target. The UiO-66-NH2 metal–organic framework was synthesized to improve the electrochemical response and served as a functional interface due to its high surface area. The proposed biosensor platform provides a sensitive detection of copeptin with a limit of detection of 228.5 pg/mL, offering a promising low-cost and efficient peptide-based electrochemical sensing platform.
Authors
- İlke GÜROL (ORCID: https://orcid.org/0000-0003-0676-2308)
- Cihat Taşaltın (ORCID: https://orcid.org/0000-0002-8978-802X)
- Tanıl Kocagöz (ORCID: https://orcid.org/0000-0001-7211-2026)
- Kevser Buse Karadeniz (ORCID: https://orcid.org/0000-0001-5370-6865)
- Yunus Zorlu (ORCID: https://orcid.org/0000-0003-2811-1872)
- Afranur Pendar (ORCID: https://orcid.org/0000-0003-1465-2811)
- Ozge Can (ORCID: https://orcid.org/0000-0002-2063-2502)
- Ahmet Can Timuçin (ORCID: https://orcid.org/0000-0002-9483-3593)
- Duygu Nuhoğlu (ORCID: https://orcid.org/0000-0001-9168-8960)
- Esra Zayim
- Eylül Ece Işlek Camadan (ORCID: https://orcid.org/0000-0002-6722-2623)
- Gunseli Guney Kekec (ORCID: https://orcid.org/0000-0003-4580-2157)
- Başak Şentürk
Institutions
- Gebze Technical University (TR)
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (TR)
- Yıldız Technical University (TR)
- TÜBİTAK Marmara Research Center (TR)
- Kent Hastanesi (TR)
- Istanbul Technical University (TR)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-09-10
- DOI
- https://doi.org/10.1021/acsomega.6c02983
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00