Is Kmax a Reliable Endpoint for Evaluating Outcomes after CAIRS?

In ectatic corneas such as keratoconus, maximum keratometry (Kmax) is commonly used to identify the cone apex and monitor disease severity and progression. However, with the advent of tissue-additive corneal-reshaping surgical techniques such as corneal allogeneic intrastromal ring segments (CAIRS), Kmax may no longer reliably reflect the true geometric changes of the diseased cornea. Automatically generated Kmax can be influenced by localized peripheral steepening over the implanted segments, leading to misinterpretation of the actual keratometric effect. We argue that Kmax is therefore a potentially misleading outcome parameter after CAIRS. A better capture of the true regularizing effect of CAIRS may therefore be mean keratometry, keratometry measured at the preoperative Kmax location, or maximum flattening on the difference map. Standardized reporting of these metrics is needed to enhance comparability between studies.

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Publication Details

Journal
Ophthalmology and Therapy
Published
2026-09-10
DOI
https://doi.org/10.1007/s40123-026-01497-9
Primary Topic
Corneal surgery and disorders
Type
article
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article

Is Kmax a Reliable Endpoint for Evaluating Outcomes after CAIRS?

David Gunn, Hyeck-Soo Son, Maximilian Friedrich, Dimitrios Kyroudis et al.
Ophthalmology and Therapy
Corneal surgery and disorders
article

Is Kmax a Reliable Endpoint for Evaluating Outcomes after CAIRS?

David Gunn, Hyeck-Soo Son, Maximilian Friedrich, Dimitrios Kyroudis, G Auffarth, Victor A. Augustin, Soosan Jacob, David Goldblum
article en

Abstract

In ectatic corneas such as keratoconus, maximum keratometry (Kmax) is commonly used to identify the cone apex and monitor disease severity and progression. However, with the advent of tissue-additive corneal-reshaping surgical techniques such as corneal allogeneic intrastromal ring segments (CAIRS), Kmax may no longer reliably reflect the true geometric changes of the diseased cornea. Automatically generated Kmax can be influenced by localized peripheral steepening over the implanted segments, leading to misinterpretation of the actual keratometric effect. We argue that Kmax is therefore a potentially misleading outcome parameter after CAIRS. A better capture of the true regularizing effect of CAIRS may therefore be mean keratometry, keratometry measured at the preoperative Kmax location, or maximum flattening on the difference map. Standardized reporting of these metrics is needed to enhance comparability between studies.

Ophthalmology and Therapy
University of Basel (CH), Heidelberg University (DE), Augenklinik Heidelberg (DE), Queensland Eye Institute (AU), Kantonsschule Olten (CH), Dr. Agarwal's Eye Hospital (IN)
Openalex Percentile: Top 11%
Corneal surgery and disorders
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Is Kmax a Reliable Endpoint for Evaluating Outcomes after CAIRS? — David Gunn, Hyeck-Soo Son, et al. · Ophthalmology and Therapy (2026) | TGRS Research Map | TGRS