Lignans as a Potential Metabolomic Biomarker for Nut Consumption and EAT-Lancet Diet Score Adherence
Abstract Metabolomic biomarkers may represent reliable objective measurements and can be useful for assessing dietary intake and avoiding biases. The objective of this study is to identify novel metabolomic indicators of dietary patterns. Dietary, anthropometric, blood biomarkers, and urinary (poly)phenols (UPLC-ESI-QqQ-MS/MS) were collected from 138 Spanish adults. Both data- and hypothesis-driven analyses were carried out. This study found associations between the consumption of EAT nuts and total EAT (p < 0.005), as well as between total urinary lignans and total EAT (p ≤ 0.05). Additionally, other associations were identified between urinary lignans and EAT nuts (p < 0.005, adjusted by age, sex, and BMI; p < 0.001, adjusted by total EAT). Urinary lignans have been associated with both a potential predictor of nut consumption and a candidate surrogate for adherence to the EAT-Lancet diet in the Spanish population. These results will translationally contribute to precision dietary intake assessment.
Authors
- Cristina M. Fernández-Díaz (ORCID: https://orcid.org/0000-0003-0539-7636)
- Cristina Del Burgo-Gutiérrez (ORCID: https://orcid.org/0000-0003-0907-3495)
- João Tomé‐Carneiro (ORCID: https://orcid.org/0000-0002-3597-9234)
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Claudia Favari (ORCID: https://orcid.org/0000-0003-0669-2223)
- Isabel Espinosa‐Salinas (ORCID: https://orcid.org/0000-0002-9526-891X)
- R. Ruiz
- Cristiana Mignogna (ORCID: https://orcid.org/0000-0001-8630-6040)
- J. Alfredo Martínéz (ORCID: https://orcid.org/0000-0001-5218-6941)
- Edwin Fernández-Cruz
- María García-Beccaria
- Miguel A. Rubio
- Pilar Matía
Institutions
- Madrid Institute for Advanced Studies (ES)
- Universidad de Valladolid (ES)
- Universidad Complutense de Madrid (ES)
- University of Parma (IT)
- Instituto de Salud Carlos III (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- Universidad Internacional De La Rioja (ES)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-09-10
- DOI
- https://doi.org/10.1021/acs.jafc.6c04434
- Primary Topic
- Nuts composition and effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
- Ministero dell'Università e della Ricerca
- Horizon 2020 Framework Programme