Effects on atrial fibrillation symptom burden of an obesity-focused cardiac rehabilitation program: Insights from the OPTICARE XL trial

Obesity is a major modifiable risk factor for atrial fibrillation (AF) [ 1 ]. Sustained weight loss and regular exercise are therefore key components of AF management [ 2 ]. In symptomatic AF populations, comprehensive risk factor management programmes targeting weight loss, physical activity, and behavioural change have been associated with reduced AF recurrence and symptom burden [ 1 , 3 , 4 ]. Cardiac rehabilitation (CR) provides a scalable framework for lifestyle modification, risk factor management (including weight loss), and improvement of exercise capacity and quality of life [ 5 ]. Whether CR, particularly when tailored for patients with obesity, is effective to reduce AF symptom burden remains uncertain [ 6 ]. We therefore evaluated the effect of an obesity-focused CR programme on AF symptom burden in patients with non-valvular AF [ 7 ].

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Publication Details

Journal
Netherlands Heart Journal
Published
2026-09-09
DOI
https://doi.org/10.1007/s12471-026-02079-x
Primary Topic
Atrial Fibrillation Management and Outcomes
Type
article
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article

Effects on atrial fibrillation symptom burden of an obesity-focused cardiac rehabilitation program: Insights from the OPTICARE XL trial

N Tenbult - Van Limpt, Iris den Uijl, Rita Van den Berg - Emons, Madoka Sunamura et al.
Netherlands Heart Journal
Atrial Fibrillation Management and Outcomes
article

Effects on atrial fibrillation symptom burden of an obesity-focused cardiac rehabilitation program: Insights from the OPTICARE XL trial

N Tenbult - Van Limpt, Iris den Uijl, Rita Van den Berg - Emons, Madoka Sunamura, Nienke ter Hoeve, Yuan Lü, Eric Boersma, Rutger Brouwers, Hareld Kemps, Richard A. J. Post
article en

Abstract

Obesity is a major modifiable risk factor for atrial fibrillation (AF) [ 1 ]. Sustained weight loss and regular exercise are therefore key components of AF management [ 2 ]. In symptomatic AF populations, comprehensive risk factor management programmes targeting weight loss, physical activity, and behavioural change have been associated with reduced AF recurrence and symptom burden [ 1 , 3 , 4 ]. Cardiac rehabilitation (CR) provides a scalable framework for lifestyle modification, risk factor management (including weight loss), and improvement of exercise capacity and quality of life [ 5 ]. Whether CR, particularly when tailored for patients with obesity, is effective to reduce AF symptom burden remains uncertain [ 6 ]. We therefore evaluated the effect of an obesity-focused CR programme on AF symptom burden in patients with non-valvular AF [ 7 ].

Netherlands Heart Journal
Radboud University Nijmegen (NL), Erasmus MC (NL), Máxima Medisch Centrum (NL), Capri Hartrevalidatie (NL), Eindhoven University of Technology (NL)
Good health and well-being
Openalex Percentile: Top 10%
Atrial Fibrillation Management and Outcomes
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