Prognostic Impact of Domiciliary Care Prior to Transcatheter Aortic Valve Implantation: A Nationwide Study

Abstract Background Domiciliary care can serve as a marker of frailty and vulnerability, which may influence outcomes following TAVI. The relationship between receipt of domiciliary care prior to TAVI and clinical outcomes has not been systematically evaluated and may influence patient selection and pre-procedural counseling. Method The study population included all adult patients with a diagnosis of aortic stenosis undergoing first time TAVI from January 1, 2015, to December 31, 2023. Patients were categorized into those with and without domiciliary care within 1 year prior to TAVI. Patients were followed for 1 year after TAVI. All-cause mortality was assessed using Kaplan-Meier estimates and multivariable Cox proportional hazards models. Cumulative days of hospitalization within 1 year after TAVI were calculated and categorized as 0–14 days and >14 days. The association between domiciliary care and > 14 cumulative days of hospitalization was evaluated using multivariable logistic regression. Results We identified 7,607 patients undergoing TAVI, 541 (7.1%) with domiciliary care (76.7% living alone; 39.4% men; median age 83 years) and 7,066 (92.9%) without domiciliary care (40.5% living alone; 59.4% men; median age 81 years). Overall, patients with domiciliary care carried a higher comorbidity burden and were more frequently classified in higher frailty groups. From discharge, the absolute 1-year risk of death was 21.5% in patients with domiciliary care and 6.4% in patients without. In adjusted analysis, patients with domiciliary care had an increased associated 1-year mortality (HR 3.30; 95% CI 2.65–4.10, p < 0.0001) compared to those without domiciliary care. Domiciliary care was also associated with higher odds of >14 cumulative days of hospitalization (reference 0-14 days), within 1 year after TAVI (OR 2.94; 95% CI 2.41-3.59, p < 0.0001). Conclusion Patients receiving domiciliary care before undergoing TAVI had a higher mortality and cumulative days of hospitalization within 1 year following the procedure, highlighting a high-risk group of patients. More research is needed to improve risk stratification of TAVI patients.