Exploring the Anticancer Potential of Schiff Base Complexes: A Mini‐Review

Schiff bases are well known for their ability to form stable coordination compounds with several transition metals, making them valuable for medicinal chemistry purposes. These metal‐based compounds have attracted significant attention due to their enhanced biological activities, particularly their ability to act toward anticancer chemotherapy. This mini‐review provides a comprehensive overview of Schiff base complexes reported over the last 5 years, highlighting the recent advances related to their biological investigations. Cytotoxicity and interactions with biological targets have been detailed. The mechanisms underlying the capacity of these complexes to induce cell death in cancer cells are also described.

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Journal
ChemMedChem
Published
2026-09-09
DOI
https://doi.org/10.1002/cmdc.70484
Primary Topic
Metal complexes synthesis and properties
Type
article
Field-Weighted Citation Impact
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article

Exploring the Anticancer Potential of Schiff Base Complexes: A Mini‐Review

Sabir Khan, José Clayston Melo Pereira, Marcos V. Palmeira‐Mello, Atif Ahmad et al.
ChemMedChem
Metal complexes synthesis and properties
article

Exploring the Anticancer Potential of Schiff Base Complexes: A Mini‐Review

Sabir Khan, José Clayston Melo Pereira, Marcos V. Palmeira‐Mello, Atif Ahmad, Anam
article en

Abstract

Schiff bases are well known for their ability to form stable coordination compounds with several transition metals, making them valuable for medicinal chemistry purposes. These metal‐based compounds have attracted significant attention due to their enhanced biological activities, particularly their ability to act toward anticancer chemotherapy. This mini‐review provides a comprehensive overview of Schiff base complexes reported over the last 5 years, highlighting the recent advances related to their biological investigations. Cytotoxicity and interactions with biological targets have been detailed. The mechanisms underlying the capacity of these complexes to induce cell death in cancer cells are also described.

ChemMedChemVol. 21(17)
Universidade Federal de Pelotas (BR), Universidade Federal de São Carlos (BR), Universidade Estadual Paulista (Unesp) (BR)
Good health and well-being
Openalex Percentile: Top 13%
Metal complexes synthesis and properties
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