Triglyceride-glucose index and personal anxiety among individuals aged 25—44 years

Objective. To establish the associations between the triglyceride-glucose index and trait anxiety in at open population of individuals aged 25 to 44 years in Novosibirsk. Materials and methods. A random representative sample of individuals aged 25 to 44 years (n=975, comprising 43.7% males) was examined from 2013 to 2017 in one of the districts of Novosibirsk at the Institute of Internal and Preventive Medicine, a branch of the federal research center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences. The response rate for this study was 71%. General examinations and medical histories were collected using standard methods delineated in the WHO MONICA psychosocial program. Trait anxiety was evaluated employing the Spielberger Trait Anxiety Scale. Blood chemistry tests were conducted in the laboratory of clinical, biochemical, and hormonal studies at the Institute of Internal and Preventive Medicine, a branch of the federal research center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences. Results. In the upper decile (>90), males with moderate and high levels of trait anxiety exhibited TyG1 scores of 9.64 [9.44; 9.94] and TyG2 scores of 5.16 [5.06; 5.31], which were significantly higher than those with low anxiety levels, with scores of 5.16 [5.06; 5.31] and 5.08 [5.00; 5.19], respectively (p<0.05). In the upper decile (≥90), the probability of high and moderate trait anxiety increased with each unit increase in TyG, as observed in model 1 (OR=4.7), model 2 (OR=5.8), model 3 (OR=8.2), and model 4 (OR=8.2), with statistical significance at p<0.05. In model 3, low number of close contacts were indicated as a predictor of anxiety (OR=3.1, p<0.05). Conversely, in the lower quartile (≤25), higher TyG1-BMI and TyG2–BMI scores were found in males with high and moderate trait anxiety, recorded at 172.94 [162.61; 176.70] and 93.81 [88.17; 95.87], respectively, compared to males exhibiting low anxiety, who had scores of 163.01 [154.72; 172.85] and 88.94 [84.39; 93.85] (p<0.05). Conclusions. This study identified significant associations between elevated trait anxiety and increased triglyceride-glucose index.