Pharmacokinetics of clofazimine tablet formulation in children with rifampicin-resistant tuberculosis in CATALYST, a multi-site international trial
We evaluated the pharmacokinetics of a novel child-friendly 50 mg clofazimine tablet formulation that disperses quickly in water, compared to traditional gel capsules, in 36 children routinely treated for rifampicin-resistant tuberculosis. No substantial pharmacokinetic difference was observed between tablets and gel capsules, supporting the tablet formulation use for paediatric dosing.
Authors
- Aarti Kinikar (ORCID: https://orcid.org/0000-0001-9466-1130)
- Elin M. Svensson (ORCID: https://orcid.org/0000-0002-0093-6445)
- Ingrid Courtney
- Yuanxi Zou (ORCID: https://orcid.org/0000-0003-0547-390X)
- Pragathi Kamath
- Anneke Catharina Hesseling (ORCID: https://orcid.org/0000-0001-9399-9834)
- Anthony J. Garcia‐Prats (ORCID: https://orcid.org/0000-0002-9280-1950)
- Vandana Kulkarni (ORCID: https://orcid.org/0000-0002-3488-2692)
- Lubbe Wiesner (ORCID: https://orcid.org/0000-0002-9070-8699)
- Paolo Denti (ORCID: https://orcid.org/0000-0001-7494-079X)
- Louvina E. van der Laan (ORCID: https://orcid.org/0000-0002-3584-7477)
- Mats O. Karlsson (ORCID: https://orcid.org/0000-0003-1258-8297)
- Heather Draper (ORCID: https://orcid.org/0000-0002-0020-4252)
- Mandar Paradkar (ORCID: https://orcid.org/0000-0001-9843-4656)
- Megan Palmer (ORCID: https://orcid.org/0000-0002-2534-2483)
- Dessa Jean O Casalme
- Melchor V G Frias
Institutions
- Uppsala University (SE)
- University of Wisconsin–Madison (US)
- Desmond Tutu HIV Foundation (ZA)
- Johns Hopkins University (US)
- Radboud University Nijmegen (NL)
- University of Cape Town (ZA)
- B. J. Medical College & Sassoon Hospital (IN)
- Stellenbosch University (ZA)
- Radboud University Medical Center (NL)
- De La Salle University – Dasmariñas (PH)
Publication Details
- Journal
- Journal of the Pediatric Infectious Diseases Society
- Published
- 2026-09-09
- DOI
- https://doi.org/10.1093/jpids/piag089
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00