Massive Laryngeal Amyloidosis: A Case Report with Long-term Follow-up

Abstract Amyloidosis is a multisystem disease characterized by the deposition of abnormally folded fibrillar proteins (amyloid) in the extracellular matrix, leading to progressive organ dysfunction. It may present in systemic or localized (focal) forms. Localized amyloidosis is diagnosed only after excluding systemic involvement. Among sites of isolated amyloid deposition, the larynx is the most common in the head and neck region. Treatment options for focal laryngeal amyloidosis include endoscopic CO 2 laser, open surgery, and close monitoring. Recurrence is frequent after treatment. In selected cases with extralaryngeal extension, unclassifiable histology, and inability to definitively exclude systemic involvement despite comprehensive negative evaluations, cautious observation without surgical intervention may represent an appropriate approach to minimize morbidity. In this case report, we present a patient diagnosed with massive laryngeal amyloidosis who experienced diagnostic difficulty in distinguishing between systemic and localized forms and was managed with close follow-up without surgery. Over 2 years of follow-up, no disease progression was observed, eliminating potential morbidity and complications associated with surgery.