Dynamic Echocardiographic Trajectory Phenotypes During Veno‐Arterial Extracorporeal Membrane Oxygenation and Their Association With In‐Hospital Mortality: A Multicenter Cohort Study

{"BACKGROUND:":[0],"Current":[1],"risk":[2,86],"stratification":[3],"for":[4,42,158],"veno-arterial":[5,38,174],"extracorporeal":[6,39,175],"membrane":[7,40,176],"oxygenation":[8,41],"relies":[9],"on":[10],"static":[11,191],"assessments,":[12],"ignoring":[13],"dynamic":[14,90,127],"cardiac":[15,171],"evolution.":[16],"We":[17,33],"aimed":[18],"to":[19,58,71,123,173,181],"identify":[20,72,166],"longitudinal":[21],"echocardiographic":[22,60,164],"trajectory":[23,73],"phenotypes":[24,91,128,168],"and":[25,53,83,102,114],"evaluate":[26],"their":[27],"association":[28],"with":[29,76,132,143],"in-hospital":[30],"mortality.":[31,133],"METHODS:":[32],"analyzed":[34],"2034":[35],"adults":[36],"receiving":[37],"cardiogenic":[43],"shock":[44],"from":[45,179],"a":[46],"multicenter":[47],"registry.":[48],"Latent":[49],"class":[50],"mixed":[51],"models":[52],"probabilistic":[54],"template-matching":[55],"were":[56,78,92,129],"applied":[57],"serial":[59],"data":[61],"(left":[62],"ventricular":[63,69],"ejection":[64],"fraction,":[65],"end-diastolic":[66],"diameter,":[67],"right":[68],"parameters)":[70],"phenotypes.":[74],"Associations":[75],"mortality":[77,141],"evaluated":[79],"using":[80],"multivariable":[81],"Cox":[82],"Fine-Gray":[84],"competing":[85],"models.":[87],"RESULTS:":[88],"Four":[89],"identified:":[93],"Dyn-A":[94,136],"(\\"Refractory":[95],"Stagnation,\\"":[96],"17.0%),":[97],"featuring":[98],"persistent":[99],"systolic":[100],"suppression":[101],"progressive":[103,182],"dilation;":[104],"Dyn-B":[105,145],"(\\"Isolated":[106],"LV":[107],"Recovery,\\"":[108,117],"14.9%);":[109],"Dyn-C":[110],"(\\"Biventricular":[111],"Failure,\\"":[112],"6.1%);":[113],"Dyn-D":[115],"(\\"Gradual":[116],"61.9%).":[118],"Static":[119],"baseline":[120,159],"phenotyping":[121],"failed":[122],"stratify":[124],"survival.":[125],"Conversely,":[126],"independently":[130],"associated":[131],"The":[134],"high-risk":[135],"phenotype":[137],"exhibited":[138],"significantly":[139],"higher":[140],"compared":[142],"the":[144],"profile":[146],"(adjusted":[147],"hazard":[148],"ratio":[149],"1.71,":[150],"95%":[151],"CI":[152],"1.35-2.16),":[153],"remaining":[154],"significant":[155],"after":[156],"adjusting":[157],"illness":[160],"severity.":[161],"CONCLUSIONS:":[162],"Dynamic":[163],"trajectories":[165],"distinct":[167],"reflecting":[169],"divergent":[170],"responses":[172],"oxygenation,":[177],"ranging":[178],"recovery":[180],"maladaptation.":[183],"Longitudinal":[184],"monitoring":[185],"provides":[186],"essential":[187],"prognostic":[188],"utility":[189],"beyond":[190],"admission":[192],"assessments.":[193]}