The Orexin System—A Key Component of Sleep Regulatory Networks and Involvement in Narcolepsy

In this Perspective, 2026 Albert Lasker Basic Medical Research Award winners Emmanuel Mignot, MD, PhD, and Masashi Yanagisawa, MD, PhD, discuss their identification of the brain peptide orexin and how it relates to sleep, specifically orexin deficiency and narcolepsy.

Authors

Emmanuel Mignot
Masashi Yanagisawa

Institutions

University of Tsukuba (JP)
Palo Alto University (US)
Stanford University (US)

Publication Details

Journal: JAMA
Published: 2026-09-09
DOI: https://doi.org/10.1001/jama.2026.15598
Primary Topic: Sleep and Wakefulness Research
Type: article
Field-Weighted Citation Impact: 0.00

Controls

|||

ALL TIME

JAN

FEB

MAR

APR

MAY

JUN

JUL

AUG

SEP

article

The Orexin System—A Key Component of Sleep Regulatory Networks and Involvement in Narcolepsy

Emmanuel Mignot, Masashi Yanagisawa

Sep 9, 2026

JAMA

Sleep and Wakefulness Research

article

The Orexin System—A Key Component of Sleep Regulatory Networks and Involvement in Narcolepsy

Emmanuel Mignot, Masashi Yanagisawa

September 9, 2026article en

Abstract

JAMA

University of Tsukuba (JP), Palo Alto University (US), Stanford University (US)

Good health and well-being

Openalex Percentile: Top 9%

Sleep and Wakefulness Research

DOI Source OpenAlex

AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

The Orexin System—A Key Component of Sleep Regulatory Networks and Involvement in Narcolepsy — Emmanuel Mignot, Masashi Yanagisawa · JAMA (2026) | TGRS Research Map | TGRS