Silver‐Mediated Deuterium Labelling of Quinones and Related Compounds by Hydrogen Isotope Exchange With D 2 O
ABSTRACT We report a silver‐catalyzed hydrogen isotope exchange reaction that enables direct deuteration of quinones and related scaffolds, using readily available D 2 O as an isotopic source. The homogeneous Ag 2 SO 4 system provides high isotopic enrichment, up to 99%, with excellent regioselectivity across diverse frameworks, including substituted para ‐naphthoquinones, anthraquinones, coumarins, quinolinones, and chromones. We also developed a heterogeneous version of the same reaction by supporting silver nanoparticles on carbon nanotubes. The nanohybrid catalyst maintains high performance and allows for easy removal of the catalyst from the final product through filtration. The dual homogeneous/heterogeneous approaches pioneer quinone hydrogen isotope exchange, providing practical and straightforward access to isotopologues.
Authors
- Joyce C. Oliveira
- Mateus P. Nunes (ORCID: https://orcid.org/0000-0003-4796-3448)
- Guilherme A. M. Jardim (ORCID: https://orcid.org/0000-0002-9882-3085)
- Eric Doris (ORCID: https://orcid.org/0000-0003-1318-602X)
- Valérie Geertsen (ORCID: https://orcid.org/0000-0002-1939-0446)
- Eufrânio N. da Silva Júnior (ORCID: https://orcid.org/0000-0003-1281-5453)
- F. Miserque
- Edmond Gravel (ORCID: https://orcid.org/0000-0001-6077-1016)
Institutions
- Universidade Federal de Minas Gerais (BR)
- Centre National de la Recherche Scientifique (FR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- CEA Paris-Saclay (FR)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2026-09-08
- DOI
- https://doi.org/10.1002/chem.71584
- Primary Topic
- Chemical Reactions and Isotopes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Horizon 2020 Framework Programme