Development of Chondroitin Sulfate ‑ Stabilized PLGA Microspheres of Exenatide via Polarity Gradient Extraction

{"The":[0,29,83,122,141],"present":[1],"work":[2],"describes":[3],"the":[4,205],"development":[5],"and":[6,24,35,49,77,92,115,124,136,180,197],"optimization":[7],"of":[8,19,52,55,87,102,154,173],"a":[9,22,188],"poly":[10],"(lactide-co-":[11],"glycolide)":[12],"based":[13],"sustained":[14,181],"release":[15,51,117,159,162],"injectable":[16],"microsphere":[17,81,193],"formulation":[18,142],"exenatide":[20,34],"using":[21,104],"coacervation":[23],"in":[25,176,187],"oil":[26],"drying":[27,123],"process.":[28],"internal":[30],"phase":[31],"composition,":[32],"containing":[33],"stabilizer,":[36],"were":[37],"evaluated":[38],"to":[39,71,110,119],"identify":[40],"critical":[41],"parameters":[42],"affecting":[43],"stability,":[44],"drug":[45,68,174],"loading,":[46],"particle":[47,65],"morphology,":[48],"burst":[50,75,116],"exenatide.":[53],"Incorporation":[54],"chondroitin":[56],"sulfate(0.5-2%":[57],"w/w),":[58],"formed":[59],"stable":[60,144],"uniform":[61,94],"coacervates":[62],"providing":[63],"consistent":[64],"size":[66],"distribution,":[67],"loading":[69],"up":[70],"4.7%":[72],"w/w,":[73],"initial":[74],"(<1%)":[76],"impurities,":[78],"with":[79,151],"\\"shrunken\\"":[80],"morphology.":[82],"secondary":[84],"emulsification":[85],"temperature":[86],"2-8":[88,149],"°C":[89],"produced":[90],"smaller":[91],"more":[93],"particles.":[95],"A":[96],"gradient":[97],"quenching":[98],"process":[99,207],"for":[100,145,163,184],"hardening":[101],"microspheres":[103],"n":[105],"heptane:":[106],"diethyl":[107],"ether":[108],"(1:9)":[109],"(10:0)":[111],"provided":[112],"low":[113],"porosity":[114],"relative":[118],"n-Heptane":[120],"alone.":[121],"lyophilization":[125],"conditions":[126],"reduced":[127],"residual":[128],"solvent":[129],"levels":[130],"(<5000":[131],"ppm":[132],"or":[133],"below":[134],"quantitation)":[135],"improved":[137],"its":[138],"wetting":[139],"characteristics.":[140],"remained":[143],"24":[146],"months":[147],"at":[148],"°C,":[150],"minimal":[152],"loss":[153],"assay":[155],"content.":[156],"In":[157],"vitro":[158],"showed":[160],"controlled":[161],"over":[164],"one":[165],"month.":[166],"This":[167,200],"translated":[168],"into":[169,204],"approximately":[170],"28":[171,185],"days":[172,186],"exposure":[175],"rat":[177],"pharmacokinetic":[178],"studies":[179],"glycemic":[182],"control":[183],"db/db":[189],"mice,":[190],"thus,":[191],"correlating":[192],"erosion,":[194],"in‑vitro":[195],"release,":[196],"in‑vivo":[198],"outcomes.":[199],"study":[201],"provides":[202],"insight":[203],"manufacturing":[206],"dynamics.":[208]}