A conversation on human brain clearance

Brain clearance is essential for eliminating metabolic byproducts and macromolecules to maintain brain homeostasis. In this Q&A, four experts share their views on how the brain clears waste products, why these clearance pathways are essential for maintaining brain health, and how their dysfunction may contribute to neurological diseases. The discussion explores current imaging approaches, key measurement challenges, methodological limitations, and emerging technologies that could improve our understanding of brain clearance in humans as well as diagnosis, monitoring, and treatment of brain disorders.