Stage‐Adaptive Therapy for Infected Diabetic Wound Through Photothermal‐Enhanced Sonocatalytic Antibacterial and Repair Activation

ABSTRACT Diabetic chronic wounds remain nonhealing largely due to persistent bacterial infection, reactive oxygen species (ROS) accumulation, and impaired tissue remodeling. Although nanozyme‐based wound healing strategies have been widely explored, most of them rely on multiple components to overcome multi‐stage healing barriers, which often makes the system complex and difficult to achieve stage‐adaptive functions. Here, we developed a simple and stage‐adaptive platform (MF127) by integrating a thermosensitive hydrogel with high‐content 1T phase‐engineered MoSe 2 nanosheets (1T‐MoSe 2 ) as the only active nanozyme component. The MF127 hydrogel exhibits injectability, sprayability, and rapid sol‐gel transition, enabling conformal coverage of irregular wounds. Under near‐infrared (NIR) and ultrasound (US) stimulation, MF127 acts as a sonosensitizer for ROS generation through photothermal‐enhanced sonocatalytic effects, eliminating both planktonic bacteria and biofilms. Under non‐stimulated conditions, MF127 exhibits antioxidant enzyme‐like activity, reducing excessive oxidative stress and promoting M2‐like macrophage phenotype modulation. Furthermore, MF127 also actively promotes wound healing through fibroblast activation and extracellular matrix (ECM) remodeling in vivo. This work presents a simplified, stage‐adaptive platform that integrates antibacterial action, antioxidation, and regeneration to meet the needs of infected diabetic wound management.