Interventional Treatment of Arterial Hypertension in The Modern Era: An Updated Review from the Young Investigator Group of the European Society of Hypertension

Achievement of blood pressure targets in hypertensive patients is a challenge for clinicians despite the different classes of drugs currently available. For this reason, taking advantage of the technological progress, new interventional strategies have been proposed. Each of these approaches acts on autonomic and vascular regulation, critical components of hypertension pathophysiology with the aim to recalibrate aberrant sympathetic activation and vascular dysfunction. Renal artery denervation is the only modality currently supported by guideline recommendations in selected patients. Baroreflex activation therapy, and carotid body modulation, thanks to good experimental results, are under evaluation as promising strategies. Concurrently, newer modalities, such as deep brain stimulation, cardiac neuromodulation, and arteriovenous shunts, are emerging with promising early data. The present narrative review provides an overview of interventional treatments for hypertension, describing their efficacy, mechanism of action, safety, and side effects. As clinical research progresses, there is the possibility that these techniques will emerge as promising treatment options for patients with resistant hypertension in the near future.

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Publication Details

Journal
High Blood Pressure & Cardiovascular Prevention
Published
2026-09-06
DOI
https://doi.org/10.1007/s40292-026-00821-5
Primary Topic
Blood Pressure and Hypertension Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Interventional Treatment of Arterial Hypertension in The Modern Era: An Updated Review from the Young Investigator Group of the European Society of Hypertension

Jovana Petrovic, Andrej Porčnik, Marijana Vučković, Ariadni Menti et al.
High Blood Pressure & Cardiovascular Prevention
Blood Pressure and Hypertension Studies
article

Interventional Treatment of Arterial Hypertension in The Modern Era: An Updated Review from the Young Investigator Group of the European Society of Hypertension

Jovana Petrovic, Andrej Porčnik, Marijana Vučković, Ariadni Menti, Alexandr Ceasovschih, Niki Katsiki, Diana Ferrão, Karel Lábr, Andrej Belančić, Yusuf Ziya Şener, Costantino Mancusi, Christina Antza, Justine Huart, Ilaria Fucile, Petra Sinigoj Porcnik
article en

Abstract

Achievement of blood pressure targets in hypertensive patients is a challenge for clinicians despite the different classes of drugs currently available. For this reason, taking advantage of the technological progress, new interventional strategies have been proposed. Each of these approaches acts on autonomic and vascular regulation, critical components of hypertension pathophysiology with the aim to recalibrate aberrant sympathetic activation and vascular dysfunction. Renal artery denervation is the only modality currently supported by guideline recommendations in selected patients. Baroreflex activation therapy, and carotid body modulation, thanks to good experimental results, are under evaluation as promising strategies. Concurrently, newer modalities, such as deep brain stimulation, cardiac neuromodulation, and arteriovenous shunts, are emerging with promising early data. The present narrative review provides an overview of interventional treatments for hypertension, describing their efficacy, mechanism of action, safety, and side effects. As clinical research progresses, there is the possibility that these techniques will emerge as promising treatment options for patients with resistant hypertension in the near future.

High Blood Pressure & Cardiovascular Prevention
University of Ljubljana (SI), University of Rijeka (HR), University of Liège (BE), International Hellenic University (GR), National and Kapodistrian University of Athens (GR), European University Cyprus (CY), Masaryk University (CZ), Ljubljana University Medical Centre (SI), Erasmus MC (NL), Hospital de São João (PT), Grigore T. Popa University of Medicine and Pharmacy (RO), Papageorgiou General Hospital (GR), Administração Regional de Saúde de Lisboa e Vale do Tejo (PT), Federico II University Hospital (IT), Centre Hospitalier Universitaire de Liège (BE), University of Naples Federico II (IT), Erasmus University Rotterdam (NL), University of Split (HR)
Università degli Studi di Napoli Federico II
Good health and well-being
Openalex Percentile: Top 11%
Blood Pressure and Hypertension Studies
DOIOpen Access PDFOpenAlex
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