Electrochemical Nickel-Catalyzed Cross-Electrophile Coupling: A Sustainable Platform for C(sp3)–C(sp3)/C(sp2) Bond Construction

Abstract An electrochemical nickel-catalyzed cross-electrophile coupling reaction of organic halides with cyclosulfonium salts to construct C(sp3)–C(sp3)/C(sp2) bonds is reported. This highly selective synthetic approach demonstrates significant practical utility, as evidenced by its broad substrate scope encompassing C(sp3)–/C(sp2)–iodides, while maintaining excellent functional group tolerance, particularly challenging late-stage functionalization applications. Moreover, density functional theory (DFT) calculations are employed to systematically evaluate the Gibbs free energy profile of key intermediates along the proposed nickel-catalyzed reaction pathway, thereby providing robust theoretical support for the mechanistic feasibility of the transformation.