Chlorhexidine or Povidone‐Iodine for CIED Procedures? Lessons From CHLOVIS and WRAP‐IT

Cardiac implantable electronic device (CIED) infection remains one of the most consequential complications of electrophysiology practice.Even in contemporary series, a device infection may lead to prolonged hospitalization, complete system extraction, antimicrobial therapy, reimplantation, and excess mortality [ 1-3 ].Because most causative microorganisms originate from the patient's endogenous skin flora, preincisional antisepsis represents a simple and potentially modifiable component of prevention [ 1-3 ].The recently published CHLOVIS randomized trial now provides the first large CIED-specific randomized comparison of 2% alcohol-based chlorhexidine and alcohol-based povidone-iodine, and its findings can be interpreted alongside the procedural analysis from WRAP-IT [ 4-6 ].