Serum thioredoxin at allogeneic haematopoietic stem cell transplantation predicts acute graft‐versus‐host disease

Thioredoxin (TXN) is a component of a major reductive system in various eukaryotes. Although oxidative stress is considered to contribute to the development of acute graft-versus-host disease (GVHD), the clinical significance of TXN remains to be elucidated. The current study included 118 patients who had undergone their first allogeneic haematopoietic stem cell transplantation (allo-HSCT) between 2022 and 2025, and their serum samples at day 0 were sequentially collected (training cohort). The study also assessed 47 patients who had undergone their first allo-HSCT between 2012 and 2015 and whose serum at around day 0 had previously been cryopreserved and was available (validation cohort). The high-TXN group showed a lower cumulative incidence of grade II-IV acute GVHD (100-day incidence: 47.5% vs. 59.2%), although the difference did not reach statistical significance (p = 0.058). The validation cohort demonstrated similar results (0% vs. 35.8%, p = 0.053). However, multivariate analysis revealed that high-TXN group was significantly associated with a reduced risk of acute GVHD (hazard ratio [HR] 0.48, p = 0.031). In addition, the combination of TXN with clinical factors enhanced the predictive potential for acute GVHD compared with that of clinical factors alone (p = 0.0039). TXN might be useful for predicting acute GVHD and could contribute to the establishment of a prediction model.

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Publication Details

Journal
British Journal of Haematology
Published
2026-09-06
DOI
https://doi.org/10.1111/bjh.70739
Primary Topic
Redox biology and oxidative stress
Type
article
Field-Weighted Citation Impact
0.00

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article

Serum thioredoxin at allogeneic haematopoietic stem cell transplantation predicts acute graft‐versus‐host disease

Masakatsu Kawamura, Masaharu Tamaki, Akari Matsuoka, Yuhei Nakamura et al.
British Journal of Haematology
Redox biology and oxidative stress
article

Serum thioredoxin at allogeneic haematopoietic stem cell transplantation predicts acute graft‐versus‐host disease

Masakatsu Kawamura, Masaharu Tamaki, Akari Matsuoka, Yuhei Nakamura, Yoshinobu Kanda, Yuya Nakata, Ayumi Gomyo, Yosuke Okada, Aki Tanihara, Hideki Nakasone, Shinichi Kako, Shun‐ichi Kimura, Tomohiro Meno, Nozomu Yoshino, Yukiko Misaki, Junko Takeshita, Machiko Kusuda, Shunto Kawamura, Takuto Ishikawa, Koki Hashino, Kaisuke Yamamoto, Kosuke Takano, Kazuki Yoshimura
article en

Abstract

Thioredoxin (TXN) is a component of a major reductive system in various eukaryotes. Although oxidative stress is considered to contribute to the development of acute graft-versus-host disease (GVHD), the clinical significance of TXN remains to be elucidated. The current study included 118 patients who had undergone their first allogeneic haematopoietic stem cell transplantation (allo-HSCT) between 2022 and 2025, and their serum samples at day 0 were sequentially collected (training cohort). The study also assessed 47 patients who had undergone their first allo-HSCT between 2012 and 2015 and whose serum at around day 0 had previously been cryopreserved and was available (validation cohort). The high-TXN group showed a lower cumulative incidence of grade II-IV acute GVHD (100-day incidence: 47.5% vs. 59.2%), although the difference did not reach statistical significance (p = 0.058). The validation cohort demonstrated similar results (0% vs. 35.8%, p = 0.053). However, multivariate analysis revealed that high-TXN group was significantly associated with a reduced risk of acute GVHD (hazard ratio [HR] 0.48, p = 0.031). In addition, the combination of TXN with clinical factors enhanced the predictive potential for acute GVHD compared with that of clinical factors alone (p = 0.0039). TXN might be useful for predicting acute GVHD and could contribute to the establishment of a prediction model.

British Journal of Haematology
Jichi Medical University (JP), Jichi Medical University Saitama Medical Center (JP)
Japan Agency for Medical Research and Development, Jichi Medical University, Terumo Foundation for Life Sciences and Arts, Japan Society for the Promotion of Science
Good health and well-being
Openalex Percentile: Top 18%
Redox biology and oxidative stress
DOISourceOpenAlex
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