Unicuspid Aortic Valve: A Review of Literature
Unicuspid aortic valve (UAV) is a rare congenital heart disease that leads to aortic valve dysfunction, most commonly stenosis, but also regurgitation. It typically presents in the third to fourth decade of life. Because of its rarity, UAV is less well-characterized than other congenital valve disorders, such as the bicuspid aortic valve (BAV). Furthermore, its similarities to BAV often lead to misdiagnosis, making accurate differentiation critical for management and prognosis. This article reviews the literature on this rare condition regarding its epidemiology, embryology, genetics, clinical presentation, diagnosis, and management.
Authors
- Collins Kokuro (ORCID: https://orcid.org/0000-0002-7568-3024)
- Isaac Kofi Owusu (ORCID: https://orcid.org/0000-0002-8934-8542)
- Solomon Gyabaah (ORCID: https://orcid.org/0000-0002-5941-9733)
- Gordon Manu Amponsah (ORCID: https://orcid.org/0000-0002-0549-6290)
- Faiza Abdul-Rahman (ORCID: https://orcid.org/0000-0003-1426-6371)
- Justin Wadadaane Bagina (ORCID: https://orcid.org/0009-0001-5435-3114)
- Nana Kwame Nyanin (ORCID: https://orcid.org/0009-0000-0367-7090)
Institutions
- Komfo Anokye Teaching Hospital (GH)
- Kwame Nkrumah University of Science and Technology (GH)
- Kwame Nkrumah University (ZM)
Publication Details
- Journal
- Journal of the Heart Valve Society
- Published
- 2026-09-04
- DOI
- https://doi.org/10.1177/30494826261484712
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00