Management of glioblastoma in the elderly

Glioblastoma is the most aggressive and common malignant primary brain tumor among adults. Due to its aggressiveness, GBM entails a short median overall survival and fatal outcomes. Incidence notably increases with age, 50% of patients being diagnosed at the age of 65 or older. Given that cognitive loss is commonly confused with age-related cognitive impairment, delays in diagnosis are frequent. Furthermore, the elderly are a vulnerable group, commonly having poorer functional status, more comorbidities, and reduced tolerance to intensive treatments. Therefore, clinical and therapeutic implications should be considered within a multidisciplinary approach. The aim of the present study was to review the current knowledge on the management of glioblastoma in the elderly population (≥ 65 years).

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Publication Details

Journal
Clinical & Translational Oncology
Published
2026-09-04
DOI
https://doi.org/10.1007/s12094-026-04546-8
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Management of glioblastoma in the elderly

Edinson Caviedes, Borja López de San Vicente Hernández, Juana María Cano, Idoia Morilla et al.
Clinical & Translational Oncology
Glioma Diagnosis and Treatment
article

Management of glioblastoma in the elderly

Edinson Caviedes, Borja López de San Vicente Hernández, Juana María Cano, Idoia Morilla, Natalia Luque, Sonia Del Barco, María Ángeles Vaz Salgado, Regina Gironés Sarrió
article en

Abstract

Glioblastoma is the most aggressive and common malignant primary brain tumor among adults. Due to its aggressiveness, GBM entails a short median overall survival and fatal outcomes. Incidence notably increases with age, 50% of patients being diagnosed at the age of 65 or older. Given that cognitive loss is commonly confused with age-related cognitive impairment, delays in diagnosis are frequent. Furthermore, the elderly are a vulnerable group, commonly having poorer functional status, more comorbidities, and reduced tolerance to intensive treatments. Therefore, clinical and therapeutic implications should be considered within a multidisciplinary approach. The aim of the present study was to review the current knowledge on the management of glioblastoma in the elderly population (≥ 65 years).

Clinical & Translational Oncology
Universidad Pública de Navarra (UPNA) (ES), Hospital Universitari i Politècnic La Fe (ES), Hospital de Basurto (ES), Hospital Universitario Príncipe de Asturias (ES), Institut Català d'Oncologia (ES), Navarre Institute of Health Research (ES), Hospital Universitario Virgen de las Nieves (ES), Hospital General Universitario de Ciudad Real (ES), Navarrabiomed (ES), Hospital Universitari de Girona Doctor Josep Trueta (ES), Hospital Universitario Ramón y Cajal (ES), Universidad de Navarra (ES)
Novocure, Sociedad Española de Oncología Médica
Openalex Percentile: Top 11%
Glioma Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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