MOLECULAR ATLAS OF AGING. META-GROUP 1. GAS TRANSMITTERS AS A FUNDAMENTAL TARGET OF AGING: INTEGRATIVE APPROACH IN THE CONTEXT OF THE THEORY OF META-ENVIRONMENTS AND META-REGULATORS
{"Relevance.":[0],"The":[1],"global":[2],"burden":[3,78],"of":[4,14,42,52,58,70,76,79,87,99,102,117,128,143,156,170,173,231,271,280,295,305,313,322],"age-associated":[5,323],"diseases":[6,324],"continues":[7],"to":[8,33,74,132,222,267],"grow,":[9],"remaining":[10],"the":[11,25,50,59,68,77,85,96,100,134,140,154,167,174,229,268,272,278,293,310,320],"main":[12],"cause":[13],"mortality":[15],"and":[16,27,40,131,159,186,197,207,215,234,239,253,288,325],"disability":[17],"in":[18,153,162,226],"developed":[19],"countries.":[20],"Modern":[21],"medicine,":[22],"which":[23,71],"preserves":[24,240],"organo-":[26],"cell-centric":[28],"paradigm,":[29],"is":[30,258,275],"not":[31],"able":[32],"offer":[34],"effective":[35],"strategies":[36],"for":[37,136,319],"systemic":[38,129],"rejuvenation":[39],"prevention":[41,321],"chronic":[43,80],"diseases.":[44],"In":[45],"previous":[46],"works,":[47],"we":[48],"proposed":[49,276],"theory":[51],"meta-environments":[53],"—":[54,90,282,291],"20":[55],"distributed":[56],"systems":[57],"body":[60],"(blood,":[61],"endothelium,":[62],"interstitium,":[63],"extracellular":[64],"matrix,":[65],"glycocalyx,":[66],"etc.),":[67],"pathology":[69],"underlies":[72],"up":[73,316],"65%":[75],"diseases,":[81],"as":[82,84,113],"well":[83],"concept":[86],"ten":[88],"meta-regulators":[89,281,314],"integrative":[91],"control":[92,230],"circuits":[93],"that":[94,124,150],"set":[95],"fundamental":[97,303],"parameters":[98],"operation":[101],"all":[103],"meta-environments.":[104],"Objective:":[105],"To":[106],"present":[107],"gas":[108],"transmitters":[109,300],"(NO,":[110],"H₂S,":[111],"CO)":[112],"a":[114,121,126,246,302],"zero":[115],"level":[116],"molecular":[118],"aging,":[119],"i.e.,":[120],"primary":[122],"failure":[123],"triggers":[125],"cascade":[127],"disorders,":[130],"substantiate":[133],"need":[135],"their":[137,254],"restoration":[138,270],"through":[139,201,228,277,309],"system":[141],"tuning":[142,279],"meta-regulators.":[144],"Results.":[145],"It":[146],"has":[147,219],"been":[148,220],"shown":[149],"age-related":[151,224],"decline":[152,225],"production":[155],"NO,":[157],"H₂S":[158,189,227,236],"CO":[160,204],"begins":[161],"middle":[163],"age,":[164],"long":[165],"before":[166],"clinical":[168],"manifestations":[169],"aging.":[171,261,306],"Each":[172],"three":[175],"gases":[176,244],"performs":[177],"unique":[178],"but":[179],"complementary":[180],"functions:":[181],"NO":[182],"regulates":[183],"endothelial":[184],"function":[185],"vascular":[187],"tone;":[188],"provides":[190],"mitochondrial":[191,241],"protection,":[192],"activates":[193],"Nrf2-dependent":[194],"antioxidant":[195],"pathways,":[196],"inhibits":[198],"cellular":[199],"senescence":[200],"Sirt3/SOD2":[202],"signaling;":[203],"exhibits":[205],"cytoprotective":[206],"anti-inflammatory":[208],"properties":[209],"by":[210],"modulating":[211],"heme":[212],"oxygenase":[213],"activity":[214],"ROS":[216],"production.":[217],"Sirt6":[218],"found":[221],"prevent":[223],"one-carbon":[232],"metabolism,":[233],"mitochondrial-directed":[235],"increases":[237],"survival":[238],"structure.":[242],"Three":[243],"form":[245],"single":[247],"signaling":[248],"network":[249,274],"(\\"Gasotransmitter":[250],"Trio":[251],"Network\\"),":[252],"synergistic":[255],"protective":[256],"effect":[257],"lost":[259],"with":[260],"A":[262],"multimodal":[263],"approach":[264],"(Quatotron":[265],"technique)":[266],"physiological":[269],"gasotransmitter":[273],"redox":[283],"regulator":[284],"(No2),":[285],"immuno-inflammatory":[286],"(No7)":[287],"neuro-autonomic":[289],"(No8)":[290],"without":[292],"introduction":[294],"exogenous":[296],"donors.":[297],"Conclusion.":[298],"Gas":[299],"are":[301],"target":[304],"Their":[307],"recovery":[308],"systematic":[311],"management":[312],"opens":[315],"new":[317],"opportunities":[318],"healthy":[326],"longevity.":[327]}
Authors
- Лагода (ORCID: https://orcid.org/0009-0009-6591-611X)
Publication Details
- Journal
- Zenodo (CERN European Organization for Nuclear Research)
- Published
- 2026-09-04
- DOI
- https://doi.org/10.5281/zenodo.22305655
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- preprint