MOLECULAR ATLAS OF AGING. META-GROUP 5. COAGULATION AND FIBRINOLYSIS FACTORS: BLOOD TRAPPED. INTEGRATIVE APPROACH IN THE CONTEXT OF META-MEDIUM THEORY AND META-REGULATORS

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Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-09-04
DOI
https://doi.org/10.5281/zenodo.22310141
Primary Topic
Blood properties and coagulation
Type
preprint
Controls
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preprint

MOLECULAR ATLAS OF AGING. META-GROUP 5. COAGULATION AND FIBRINOLYSIS FACTORS: BLOOD TRAPPED. INTEGRATIVE APPROACH IN THE CONTEXT OF META-MEDIUM THEORY AND META-REGULATORS

Лагода
Zenodo (CERN European Organization for Nuclear Research)
Blood properties and coagulation
preprint

MOLECULAR ATLAS OF AGING. META-GROUP 5. COAGULATION AND FIBRINOLYSIS FACTORS: BLOOD TRAPPED. INTEGRATIVE APPROACH IN THE CONTEXT OF META-MEDIUM THEORY AND META-REGULATORS

Лагода
preprint en

Abstract

Relevance. In the hierarchy of 22 groups of molecules affected by aging, coagulation and fibrinolysis factors rank fifth, after gasotransmitters (energy foundation), rejuvenation signaling proteins (regeneration architects), pro-inflammatory cytokines (chronic inflammatory fire), and exogenous xenobiotics (toxic load). If the first four groups are sources of damage, then the fifth group is the system that turns these injuries into fatal events. Blood, the "river of life," changes its properties with age, becoming hypercoagulant, prone to clotting even in the absence of trauma. This condition, defined as "thrombotic preparedness," is the basis of heart attacks, strokes, and thromboembolisms, the leading causes of death in the world. Aim. To present age-related dysregulation of coagulation and fibrinolysis factors as the fifth level of molecular aging, i.e., a systemic shift in the hemostatic balance that turns age-related injuries into clinical events. To substantiate the need to restore hemostatic equilibrium through the systemic tuning of meta-regulators. Results. It has been shown that with age, there is a progressive increase in the concentrations of procoagulant factors: fibrinogen, von Willebrand factor (VWF), and factor VIII. VWF increases by about 10–15 IU/dL per decade, and this increase becomes linear after 40 years. At the same time, the activity of the plasminogen activator inhibitor-1 (PAI-1), the main suppressor of fibrinolysis, which is now recognized as a key driver of aging, contributing to vascular stiffness, cell senescence, and immune ejasize, increases. PAI-1 amplifies senescence, accelerates cardiovascular aging, and disrupts β-amyloid clearance. Senescent cells directly contribute to thrombosis formation and worsen fibrinolysis. Age-related changes affect not only factor concentrations, but also the ultrastructure of the fibrin network: in the elderly, stiffer clots with delayed lysis are formed. A direct relationship between hypercoagulability markers and the risk of cognitive decline was revealed. A multimodal approach (Quatotron technique) to physiological restoration of hemostatic balance through tuning of endothelial function, redox regulator and neuro-autonomic tone was proposed. Conclusion. Coagulation and fibrinolysis factors are the fifth level of molecular aging – a bridge between accumulated damage and fatal cardiovascular events. Restoration of hemostatic balance through systemic management of meta-regulators opens up new opportunities for the prevention of thrombotic complications and healthy longevity.

Zenodo (CERN European Organization for Nuclear Research)
Blood properties and coagulation
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