NPB-1575 improves ischemic brain injury by regulating microglial polarization via IRS2 signaling pathway
Modulating microglial polarization is a promising ischemic stroke therapeutic strategy. This study confirms that the novel neuroprotectant NPB-1575 inhibits neuroinflammation and alleviates cerebral ischemic injury. It switches microglial polarization from pro-inflammatory M1 to anti-inflammatory M2 via the IRS2/Nrf2/NF-κB signaling pathway.
Authors
- Jungui Dai (ORCID: https://orcid.org/0000-0003-2989-9016)
- Songyang Sui
- Nian-ying Shang
- Liwen Zhang (ORCID: https://orcid.org/0009-0003-7342-7531)
- Jingshu Tang
- Lei Wu
- An-Hua Tao
- Xin-Nan Li
- Meng-Yao Liu
- Ying Peng
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2026-09-04
- DOI
- https://doi.org/10.1080/10286020.2026.2726155
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China