Zipper polydefluorination-monoborylation of perfluoroalkyl chains
Selective defluorination of perfluoroalkyl chains remains challenging because of the strength of C-F bonds and the inertness of perfluoroalkyl groups. Here, the authors report a zipper reaction that completely defluorinates perfluoroalkylated alkenes into synthetically useful linear alkyl boranes while preserving the carbon backbone. The reaction is scalable and allows the recovery of fluoride in the form of LiF by simple filtration. It can be further applied to gem-difluoroalkenes, which are concluded to be intermediates of the underlying iterative fluoride removal process.
Authors
- Jan Streuff (ORCID: https://orcid.org/0000-0002-8320-4353)
- Marie Deliaval (ORCID: https://orcid.org/0000-0003-1396-2818)
- Sanne L. Albers
- Johanne Köllmann
- Johanna K. Harzendorf (ORCID: https://orcid.org/0009-0006-4494-9332)
Institutions
- Uppsala University (SE)
- Science for Life Laboratory (SE)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-09-04
- DOI
- https://doi.org/10.1038/s41467-026-77437-9
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Svenska Forskningsrådet Formas
- Albert-Ludwigs-Universität Freiburg
- Carl Tryggers Stiftelse för Vetenskaplig Forskning
- Vetenskapsrådet
- Université de Fribourg
- Uppsala Universitet
- Science for Life Laboratory
- Erasmus+