Pharmacological Principles in the Use and Development of Antituberculosis Drugs

), while effective integration of these data through quantitative pharmacology tools has facilitated more rational decision-making in preclinical and clinical drug development. This new framework permits a much more extensive and efficient evaluation of the space of novel and repurposed multidrug regimens in tuberculosis with the expectation of accelerating the arrival of even shorter, safer, and more effective treatments in the clinic.