Nicholas' Story: The Molecular Basis of SCD Pain Crisis

Nicholas' Story Overview: This case discusses Nicholas' experiences with sickle cell disease. The case begins with watching a video where Nicholas and his mother, Bridget, talk about living with sickle cell disease. The case is organized into multiple sections - this version primarily explores the molecular basis of Nicholas' pain crises. Learning Objectives: The case was developed at the interface of Biology and Chemistry to enable introductory biology students explore chemical interactions that stabilize the structure and enable functions of biological molecules; and introductory chemistry students in applying their knowledge of intra- and inter-molecular forces to authentic biological contexts. By the end of the case, students should develop some basic understanding of bio-molecular structure-function relationships. Molecules explored: The primary molecule studied in this case is hemoglobin, including structures of native, mutant, and variant proteins. Implementation: The case can be implemented using either a flipped approach and/or in-class discussions.