Genetic Screening of Colombian Patients With Early-Onset Parkinson Disease
Early-onset Parkinson disease (EOPD), defined as symptom onset before 50 years of age, accounts for approximately 10% of patients and is suggested to have a greater genetic component than typical late-onset forms of the disease. Recessive variants in PRKN, PINK1, and DJ-1, are the most common genetic cause of EOPD, however, most studies are in patients of white ancestry. This study aims to analyze genetic variants in PRKN, PINK1, and DJ-1 in Colombian patients to help address the gap in EOPD genetic research of South American populations.
Authors
- Catalina Cerquera‐Cleves (ORCID: https://orcid.org/0000-0002-3874-0261)
- Zbigniew K. Wszołek (ORCID: https://orcid.org/0000-0001-5487-1053)
- Claudia Lucía Moreno López (ORCID: https://orcid.org/0009-0008-9621-5837)
- Sarah Kim-Hellmuth (ORCID: https://orcid.org/0000-0001-8791-5729)
- Marios Gavrielatos (ORCID: https://orcid.org/0000-0002-6052-5517)
- Alexandra I. Soto‐Beasley (ORCID: https://orcid.org/0000-0002-0153-1917)
- Audrey Strongosky (ORCID: https://orcid.org/0000-0003-4734-0339)
- Owen A. Ross (ORCID: https://orcid.org/0000-0003-4813-756X)
- Tobias M. Franz
- Ysabella Wijaya
Institutions
- Jacksonville College (US)
- WinnMed (US)
- Helmholtz Zentrum München (DE)
- University Children's Hospital Tübingen (DE)
- Institute of Cardiology (CO)
- Mayo Clinic in Florida (US)
- Hospital Universitario San Ignacio (CO)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Neurology Genetics
- Published
- 2026-09-01
- DOI
- https://doi.org/10.1212/nxg.0000000000200427
- Primary Topic
- Genomics and Rare Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00