A macrophage-conditioned medium model recapitulates inflammation-associated suppression of UCP-1 expression in KK-Ay mice
Macrophage-conditioned medium models are widely used in obesity research, but correspondence with obese animals has not been examined. We compared the effects of Kaempferia parviflora in this model and KK-Ay diabetic obese model mice. Anti-inflammatory effects and restoration of uncoupling protein-1 (UCP-1) expression were observed in both models, indicating that the macrophage-conditioned medium model recapitulates inflammation-associated suppression of UCP-1 expression.
Authors
- Teruo Kawada (ORCID: https://orcid.org/0000-0002-7067-4380)
- Nobuyuki Takahashi (ORCID: https://orcid.org/0000-0002-9705-662X)
- Hiromu Morimoto
- Kentaro Kaneko (ORCID: https://orcid.org/0000-0002-5003-2460)
- Tsuyoshi Goto (ORCID: https://orcid.org/0000-0003-1283-147X)
- Mariko Uehara (ORCID: https://orcid.org/0000-0003-0402-0968)
- Hisako Takahashi
- Hirofumi Inoue
Institutions
- Tokyo University of Agriculture (JP)
- Meiji University (JP)
- Kyoto University (JP)
Publication Details
- Journal
- Bioscience Biotechnology and Biochemistry
- Published
- 2026-09-01
- DOI
- https://doi.org/10.1093/bbb/zbag133
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00