Lymphomatoid Granulomatosis: Pulmonary, Neurologic, and Cutaneous Involvement—Between Infection and Cancer

Lymphomatoid granulomatosis is a rare entity associated with a relatively common virus: Epstein–Barr. The virus can induce a B-cell lymphoproliferative disorder with the characteristic histopathologic finding of lymphocytic invasion of vascular walls. The lung is the organ most affected; however, the skin and central nervous system also may be involved. Management remains challenging and must be individualized because no consensus exists regarding optimal therapy. This case report of a patient with lymphomatoid granulomatosis who presented initially with dermatologic and pulmonary involvement and who later developed neurologic compromise aims to highlight this multisystem association to encourage timely biopsy and increase diagnostic yield.