When electricity isn’t enough: ORAI channels reinforce neurovascular coupling

Neurovascular coupling ensures that active neuronal circuits receive the blood supply needed to sustain brain function. In this issue of Science Signaling , Lavanderos et al. identify STIM1-ORAI–mediated Ca 2+ entry as a mechanism that reinforces capillary-to-arteriole communication, sustaining functional hyperemia during repetitive neuronal stimulation.

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Journal
Science Signaling
Published
2026-09-01
DOI
https://doi.org/10.1126/scisignal.aek0208
Primary Topic
Ion Channels and Receptors
Type
article
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0.00
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article

When electricity isn’t enough: ORAI channels reinforce neurovascular coupling

Fabrice Dabertrand
Science Signaling
Ion Channels and Receptors
article

When electricity isn’t enough: ORAI channels reinforce neurovascular coupling

Fabrice Dabertrand
article en

Abstract

Neurovascular coupling ensures that active neuronal circuits receive the blood supply needed to sustain brain function. In this issue of Science Signaling , Lavanderos et al. identify STIM1-ORAI–mediated Ca 2+ entry as a mechanism that reinforces capillary-to-arteriole communication, sustaining functional hyperemia during repetitive neuronal stimulation.

Science SignalingVol. 19(953)
University of Colorado Anschutz Medical Campus (US)
Responsible consumption and production
Openalex Percentile: Top 13%
Ion Channels and Receptors
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When electricity isn’t enough: ORAI channels reinforce neurovascular coupling — Fabrice Dabertrand · Science Signaling (2026) | TGRS Research Map | TGRS