Co-occurrence of pfkelch13 and pfmdr1 variants in a recurrent Plasmodium falciparum infection following standard artemether-lumefantrine treatment

We report recurrent Plasmodium falciparum infection following standard artemether-lumefantrine treatment in a patient with metabolic comorbidities carrying mutant parasites presenting pfkelch13 and pfmdr1 variants, underscoring the need for genomic surveillance of antimalarial resistance and further investigation of host factors that may influence antimalarial drug exposure.

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Publication Details

Journal
International Journal of Infectious Diseases
Published
2026-09-01
DOI
https://doi.org/10.1016/j.ijid.2026.109078
Primary Topic
Malaria Research and Control
Type
article
Field-Weighted Citation Impact
0.00

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article

Co-occurrence of pfkelch13 and pfmdr1 variants in a recurrent Plasmodium falciparum infection following standard artemether-lumefantrine treatment

Márcia Melo Medeiros, Joana Laranjinha, Ana Paula Arez, Inês Lopes et al.
International Journal of Infectious Diseases
Malaria Research and Control
article

Co-occurrence of pfkelch13 and pfmdr1 variants in a recurrent Plasmodium falciparum infection following standard artemether-lumefantrine treatment

Márcia Melo Medeiros, Joana Laranjinha, Ana Paula Arez, Inês Lopes, Pedro Vitor Cravo, Raquel Azevedo, Ana Cláudia Carvalho, Ana M. Costa, Andréa Luciana S. da Silva, Sara B. Lopes
article en

Abstract

We report recurrent Plasmodium falciparum infection following standard artemether-lumefantrine treatment in a patient with metabolic comorbidities carrying mutant parasites presenting pfkelch13 and pfmdr1 variants, underscoring the need for genomic surveillance of antimalarial resistance and further investigation of host factors that may influence antimalarial drug exposure.

International Journal of Infectious Diseases
Instituto de Medicina Tropical (PY), Hospital Braga (PT), Unidade Hospitalar de Bragança (PT), Universidade Federal do Pará (BR), University of Coimbra (PT)
Fundação para a Ciência e a Tecnologia, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa
Good health and well-being
Openalex Percentile: Top 9%
Malaria Research and Control
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Co-occurrence of pfkelch13 and pfmdr1 variants in a recurrent Plasmodium falciparum infection following standard artemether-lumefantrine treatment — Márcia Melo Medeiros, Joana Laranjinha, et al. · International Journal of Infectious Diseases (2026) | TGRS Research Map | TGRS