Defining and predicting disease progression in myeloproliferative neoplasms: a proposed biomarker-driven approach
The development of precision medicine approaches in oncology has revolutionized clinical practice. Although definitions of precision medicine may vary, it is reasonably defined as the use of biomarkers to select a treatment approach for a patient to optimize the chance of response [ 1 , 2 , 3 ]. Key examples that define current standard practice include the use of genomics to guide therapy, such as FLT3 inhibitors in Acute Myeloid Leukemia (AML) with FLT3-ITD, and the use of the Oncotype Dx assay to assess the relative risk and benefit of chemotherapy in invasive Breast Cancer [ 4 , 5 ]. The number of such precision approaches in oncology continues to rapidly expand [ 1 ].
Authors
- Zi Yun Ng (ORCID: https://orcid.org/0000-0001-5050-1223)
- Steffen Koschmieder (ORCID: https://orcid.org/0000-0002-1011-8171)
- Laura C. Michaelis (ORCID: https://orcid.org/0000-0002-1798-9658)
- Aaron T. Gerds (ORCID: https://orcid.org/0000-0002-3422-1309)
- Bridget Kelly Marcellino (ORCID: https://orcid.org/0000-0001-8590-6175)
- Anand Patel (ORCID: https://orcid.org/0000-0002-0296-8686)
- Linda M S Resar (ORCID: https://orcid.org/0000-0002-4004-7060)
- Gabriela Hobbs (ORCID: https://orcid.org/0000-0002-0199-9333)
- Joseph Michael Scandura (ORCID: https://orcid.org/0000-0002-9525-143X)
- John O Mascarenhas (ORCID: https://orcid.org/0000-0002-8400-0483)
- Ghaith F. Abu-Zeinah (ORCID: https://orcid.org/0000-0002-1881-3670)
- Raajit K. Rampal (ORCID: https://orcid.org/0000-0002-0355-6368)
- Andriy Derkach (ORCID: https://orcid.org/0000-0003-2178-8493)
- Jan Philipp Bewersdorf (ORCID: https://orcid.org/0000-0003-3352-0902)
- Florian Heinrich Heidel (ORCID: https://orcid.org/0000-0003-2438-1955)
- Douglas Tremblay (ORCID: https://orcid.org/0000-0003-2584-6953)
- Andrew Kuykendall
- Richard Winneker
- Shane Mayack
Institutions
- Cleveland Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Medical College of Wisconsin (US)
- Cornell University (US)
- Yale Cancer Center (US)
- Moffitt Cancer Center (US)
- Yale University (US)
- Medizinische Hochschule Hannover (DE)
- University of Chicago (US)
- Massachusetts General Hospital (US)
- MPN Research Foundation (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- RWTH Aachen University (DE)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Leukemia
- Published
- 2026-09-01
- DOI
- https://doi.org/10.1038/s41375-026-03103-0
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Memorial Sloan-Kettering Cancer Center
- MPN Research Foundation