Indole-AhR signaling shapes emotional regulation
Wang et al. identify a gut-brain pathway in which loss of the commensal bacterium Alistipes shahii reduces indole production, prevents hippocampal indole-AhR signaling, and drives anxiety and depression behaviors in patients and mouse models of irritable bowel syndrome. 1
Authors
- Minjeong Kim (ORCID: https://orcid.org/0009-0004-7712-1684)
- Helen E. Vuong
Institutions
- University of Minnesota (US)
Publication Details
- Journal
- Cell Reports
- Published
- 2026-09-01
- DOI
- https://doi.org/10.1016/j.celrep.2026.117747
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Pew Charitable Trusts