INTERPRETIVE SUMMARIES, SEPTEMBER 2026

Identification of macrophage-inducible C-type lectin receptor stimulatory glycolipids from Lactiplantibacillus plantarum OLL2712 that induce interleukin-10 production in dendritic cells. By Shimazu et al., page 9042.Although the immunoregulatory functions of lactic acid bacteria are well recognized, the specific bacterial components responsible for these effects have only been identified in a limited number of cases.We previously demonstrated that the stimulation of macrophage-inducible C-type lectin receptor by Lactiplantibacillus plantarum OLL2712 is crucial for the induction of the anti-inflammatory cytokine interleukin-10.In this study, we identified the corresponding ligand components, revealing that monoglucosyldiacylglycerol derived from bacterial cells and glucosylceramide originating from a milk-based medium were responsible for this activity.