Proof-of-Concept Study of Hyperpolarized [1- 13 C]Pyruvate MRI in Participants with Hepatocellular Carcinoma
Hyperpolarized [1- 13 C]pyruvate MRI enabled noninvasive metabolic characterization of focal liver lesions, and alanine-indexed metrics emerged as biological markers of progression to hepatocellular carcinoma beyond CT/MRI–based Liver Imaging Reporting and Data System categorization.
Authors
- Nikolaj Bøgh (ORCID: https://orcid.org/0000-0002-0321-3269)
- Uffe Kjærgaard (ORCID: https://orcid.org/0000-0002-9188-2162)
- Steffen Ringgaard (ORCID: https://orcid.org/0000-0001-5353-7379)
- Mattias Hedegaard Kristensen (ORCID: https://orcid.org/0000-0003-4723-654X)
- Kim Sivesgaard (ORCID: https://orcid.org/0000-0001-6336-9890)
- Esben Søvsø Szocska Hansen (ORCID: https://orcid.org/0000-0001-5512-9870)
- Nichlas Vous Christensen (ORCID: https://orcid.org/0000-0001-7390-6071)
- Christoffer Laustsen (ORCID: https://orcid.org/0000-0002-0317-2911)
- Gerda Elisabeth Villadsen (ORCID: https://orcid.org/0000-0002-2757-929X)
- Lotte Bonde Bertelsen (ORCID: https://orcid.org/0000-0002-2491-3184)
- Henning Grønbæk (ORCID: https://orcid.org/0000-0001-8998-7910)
- Malene Aastrup (ORCID: https://orcid.org/0009-0005-0728-3167)
Institutions
- Aarhus University (DK)
- University of Cambridge (GB)
- Aarhus University Hospital (DK)
- Cambridge School (PT)
- Bridge University (SS)
- Regional Hospital Horsens (DK)
Publication Details
- Journal
- Radiology Imaging Cancer
- Published
- 2026-08-28
- DOI
- https://doi.org/10.1148/rycan.250784
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Danish Cancer Society Research Center