Genome-wide meQTL mapping reveals genetic control of DNA methylation in colon cancer

Methylation quantitative trait loci (meQTLs) are essential for understanding the role of DNA methylation in the genetic susceptibility to colorectal cancer (CRC). However, studies of meQTLs in East Asians and at single base-pair resolution are relatively scarce. We conducted multi-omics analysis using the whole-genome bisulfite sequencing and RNA sequencing in colon cancer samples from 250 Chinese individuals, including methylome and transcriptome correlations (eQTMs) and genetic regulation in cis (meQTLs and eQTLs).

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Publication Details

Journal
China National GeneBank DataBase
Published
2026-08-28
DOI
https://doi.org/10.26036/cnp0008089
Primary Topic
Epigenetics and DNA Methylation
Type
article
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article

Genome-wide meQTL mapping reveals genetic control of DNA methylation in colon cancer

候浩(Hou hao)
China National GeneBank DataBase
Epigenetics and DNA Methylation
article

Genome-wide meQTL mapping reveals genetic control of DNA methylation in colon cancer

候浩(Hou hao)
article en

Abstract

Methylation quantitative trait loci (meQTLs) are essential for understanding the role of DNA methylation in the genetic susceptibility to colorectal cancer (CRC). However, studies of meQTLs in East Asians and at single base-pair resolution are relatively scarce. We conducted multi-omics analysis using the whole-genome bisulfite sequencing and RNA sequencing in colon cancer samples from 250 Chinese individuals, including methylome and transcriptome correlations (eQTMs) and genetic regulation in cis (meQTLs and eQTLs).

China National GeneBank DataBase
Good health and well-being
Openalex Percentile: Top 17%
Epigenetics and DNA Methylation
DOIOpen Access PDFOpenAlex
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Genome-wide meQTL mapping reveals genetic control of DNA methylation in colon cancer — 候浩(Hou hao) · China National GeneBank DataBase (2026) | TGRS Research Map | TGRS