Biofluid Biomarkers of Ischemic Penumbra in Acute Ischemic Stroke
The ischemic penumbra is the principal therapeutic target in acute ischemic stroke (AIS). Although perfusion imaging identifies salvageable tissue, its availability is limited and contrast exposure carries risk. Validated blood-based biomarkers could serve as scalable surrogates for imaging-defined penumbrae. We conducted a systematic review and meta-analysis assessing associations between blood-based biomarkers and ischemic penumbrae.
Authors
- Maarten G. Lansberg (ORCID: https://orcid.org/0000-0002-3545-6927)
- Yuki I. Kawamura (ORCID: https://orcid.org/0000-0003-2137-6464)
- TuKiet T. Lam (ORCID: https://orcid.org/0000-0002-4850-3462)
- David S. Liebeskind (ORCID: https://orcid.org/0000-0002-5109-8736)
- Charles Wira (ORCID: https://orcid.org/0000-0002-1041-4165)
- Erum Khan (ORCID: https://orcid.org/0000-0002-1937-5270)
- Mark Reed (ORCID: https://orcid.org/0000-0003-2916-9654)
- Adam de Havenon (ORCID: https://orcid.org/0000-0001-8178-8597)
- Melissa Funaro (ORCID: https://orcid.org/0000-0001-6846-4846)
- Nishant K. Mishra (ORCID: https://orcid.org/0000-0002-9327-3707)
- Shubham Misra (ORCID: https://orcid.org/0000-0002-4920-2573)
- Pei Yi Chook
- Amr Elshahat
- Priyal Tiwari
- Ethan Y. Wang (ORCID: https://orcid.org/0000-0003-1793-9498)
- Srikant Rangaraju
Institutions
- University of Southern California (US)
- University of Cambridge (GB)
- W. M. Keck Foundation (US)
- Yale University (US)
- University of Malaya (MY)
- Stanford Health Care (US)
- Sir Ganga Ram Hospital (IN)
- Stanford Medicine (US)
- California Northstate University (US)
Publication Details
- Journal
- Neurology Open Access
- Published
- 2026-08-28
- DOI
- https://doi.org/10.1212/wn9.0000000000000169
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00