Synthesis of Naphthoquinones by Pd‐Catalyzed Heck–Matsuda Arylation of Lapachol
Direct Heck–Matsuda arylation of lapachol provides rapid access to structurally diverse naphthoquinones under homogeneous and heterogeneous palladium catalysis. The methodology features broad substrate scope, gram‐scale applicability, and unambiguous structural assignment by single‐crystal X‐ray diffraction, providing an efficient platform for the diversification of quinones.
Authors
- Rubem F. S. Menna‐Barreto (ORCID: https://orcid.org/0000-0002-1352-0641)
- Victor Feliciano dos Santos Ramos (ORCID: https://orcid.org/0009-0005-6208-1621)
- Renata Almeida
- Guilherme A. M. Jardim (ORCID: https://orcid.org/0000-0002-9882-3085)
- Eric Doris (ORCID: https://orcid.org/0000-0003-1318-602X)
- Eufrânio N. da Silva Júnior (ORCID: https://orcid.org/0000-0003-1281-5453)
- Edmond Gravel (ORCID: https://orcid.org/0000-0001-6077-1016)
- Chandrakant B. Nichinde (ORCID: https://orcid.org/0000-0002-4864-9824)
- Felipe Fantuzzi (ORCID: https://orcid.org/0000-0002-8200-8262)
- Breno U. Abreu
- Willian X. C. Oliveira
- Maria H. Araujo
- Ana L. C. Silveira
- Leonardo A. Matos (ORCID: https://orcid.org/0009-0005-1218-8172)
Institutions
- Universidade Federal de Minas Gerais (BR)
- University of Kent (GB)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Indian Institute of Science Education and Research, Bhopal (IN)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- CEA Paris-Saclay (FR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2026-08-28
- DOI
- https://doi.org/10.1002/ejoc.70790
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Greenwich
- Royal Society
- Agence Nationale de la Recherche
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Fundação Oswaldo Cruz
- Université Paris-Saclay
- Universidade Federal de Minas Gerais