Prescribing Psychiatric Drugs to Children and Adolescents

Abstract: The evidence base cited for the prescribing of psychiatric drugs typically consists of short-term RCTs that tell of drugs that reduce symptoms of a disorder better than placebo. A more robust assessment consists of reviewing evidence of multiple types. What is the mechanism of action of the drug? Does the drug-placebo difference in RCTs provide a clinically meaningful benefit? How does the treatment affect functional outcomes? Does the treatment provide a long-term benefit? What are the risks of adverse events? What are the public health outcomes for the patient group so treated? A robust review of the evidence base for the prescribing of stimulants, antidepressants, and antipsychotics to children and adolescents tells of treatments that do more harm than good, particularly over the long term.