Green synthesis and investigation of antioxidant and antimicrobial activity of benzoxazine derivatives

In this work we synthesized benzoxazine derivatives in excellent yields using multicomponent reactions of phthalaldehyde or its derivatives, primary amines, isothiocyanate, 2,4-dihydroxyacetophenone and isopropenylacetylene in the presence of catalytic amount of Cu/KF/CP@MWCNTs NCs in water at room temperature.‎ Also, the catalytic activity of the green synthesized Cu/KF/CP@MWCNTs NCs was evaluated in the reduction of organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions. The results indicated that the biosynthesized NCs have very high and effective catalytic activity for organic pollutants within few seconds. As well the antioxidant activity of some synthesized benzoxazine was studied using trapping of radical by DPPH and ferric reduction activity potential (FRAP) experiment. Also, the antimicrobial activity of some synthesized compounds proved by employing the disk diffusion test on Gram-positive and Gram-negative bacteria. The short time of reaction, high yields of product, easy separation of catalyst and products are some benefits of this procedure.