Green synthesis and investigation of biological activity of new pyrazole in ionic liquid

In this research we have synthesized new derivatives of pyrazoloazepine in high yields using multicomponent reaction of aniline, oxalyl chloride, iminoalkyl bromides, activated acetylenic compounds, and hydrazonoyl chlorides in ionic liquid at room temperature. Because of having NH group in the synthesized compounds, we investigate antioxidant property of some synthesized pyrazoloazepine by diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction experiment. Short time of reaction, high yields of product, easy separation of catalyst and products are some advantages of this procedure.

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Publication Details

Journal
Iranian Journal of Organic Chemistry (IranJOC) شیمی آلی ایران
Published
2026-08-27
DOI
https://doi.org/10.82361/1251366
Primary Topic
Multicomponent Synthesis of Heterocycles
Type
article
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article

Green synthesis and investigation of biological activity of new pyrazole in ionic liquid

IAU
Iranian Journal of Organic Chemistry (IranJOC) شیمی آلی ایران
Multicomponent Synthesis of Heterocycles
article

Green synthesis and investigation of biological activity of new pyrazole in ionic liquid

IAU
article en

Abstract

In this research we have synthesized new derivatives of pyrazoloazepine in high yields using multicomponent reaction of aniline, oxalyl chloride, iminoalkyl bromides, activated acetylenic compounds, and hydrazonoyl chlorides in ionic liquid at room temperature. Because of having NH group in the synthesized compounds, we investigate antioxidant property of some synthesized pyrazoloazepine by diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction experiment. Short time of reaction, high yields of product, easy separation of catalyst and products are some advantages of this procedure.

Iranian Journal of Organic Chemistry (IranJOC) شیمی آلی ایران
Openalex Percentile: Top 19%
Multicomponent Synthesis of Heterocycles
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Green synthesis and investigation of biological activity of new pyrazole in ionic liquid — IAU · Iranian Journal of Organic Chemistry (IranJOC) شیمی آلی ایران (2026) | TGRS Research Map | TGRS